The antitumor activity of cannabidiol on lung cancer cell lines A549 and H1299: the role of apoptosis

In the recent years, application of new antitumor drugs has focused on replacement conventional chemotherapeutics with compounds derived from natural products. Cannabidiol (CBD) is one 113 cannabinoids plant Cannabis sativa and characterized complex not entirely understood biological function. Unlike other most abundant cannabinoid in – tetrahydrocannabinol, cannabidiol low affinity to endocannabinoid receptors manifestation its activity does appear rely system. used treatment many diseases including some types cancer. The aim our study was evaluate cytotoxic effect process programmed cell death. This directly involved drugs. Two lung cancer lines, A549 expressing ?53 H1299-p53 negative, were used. Apoptosis monitored by Anexin V assay activation Caspase 3/7. We found that CBD led a dose-dependant apoptosis increase p53 positive cells. level negative H1299 cells much lower did seem be dose dependent. However, total viability similar for two which due increased necrosis observed